The relation between electroconvulsive therapy and dopamine

Introduction The use of electroconvulsive therapy (ECT) as a treatment for psychotic disorders is well-documented and effective. Despite the fact that ECT often used, precise neurobiological mechanisms supporting its effectiveness are still incompletely understood. Over pastyears, extensive research on primates, rodents, humans has begun to clarify effects seizures (ECS) neurotransmission systems such dopaminergic system. Objectives aim this paper search evidence in literature regarding dopamine Methods In order write article, we searched information most important scientific articles from Google Scholar Pubmed databases Results shock linked enhanced release receptor modification. Human studies show activates study by Rudorfer et al., it was discovered increased amount homovanillic acid (HVA), marker turnover, cerebrospinal fluid (CRF). One indicates monkeys given brief clinical course (six sessions only) exhibit significant changes presynaptic neurotransmission, with baseline function returning quadratic (‘inverted U’ shape) six weeks last treatment. According single-unit electrophysiological methods, repeated rats causes subsensitivity autoreceptors substantia nigra. Since identical those reported were also detected when single followed an acceptable treatment-free interval, decreased sensitivity time-dependent. Conclusions results support idea boosts system can be effective strategy management disorders. Disclosure Interest None Declared